【摘要】 自骆驼蓬种子中分离出一个吲哚生物碱5n,已发现这个生物碱能抑制小鼠的移植性肿瘤生长。在11.25mg/kg/d,22.5mg/kg/d和45mg/kg/d的剂量下,对S180肉瘤的抑制率为47.5～48.5％,68.8％和69～75.6％。在22.5mg/kg/d和45mg/kg/d的剂量下对网细胞肉瘤（L₁）的抑制率为41～50.8％和47～61％。在22.5mg/kg/d和45mg/kg/d的剂量下,对肝癌的抑制率分别为51.7～55％和62～66.7％。 与混合生物碱5L比较,5n显示出较高的效能,较强的抗癌活性和较广的抗瘤谱,5n有可能是骆驼蓬种子中主要的抗瘤生物碱。更多还原

【Abstract】 An indole alkaloid 5n was isolated from Peganum harmala. L. seed. It was shown that the growth of transplantable tumors in mice were inhibited by this alkaloid. The inhibitory rates on S-180 were 47.5-48.5%, 68.8% and 69%-75.6% under the doses of 11.25 mg/kg/d, 22.5mg/kg/d and 45mg/kg/d. The inhibitory rates on reticuloum-cell sarcoma (LI ) were 41-50.8% and 47-61% under the doses of 22.5mg/kg/d and 45mg. kg/d. The inhibitory rates on hepatoma were 51.7-55% and 62-66.7% under the doses of 22.5mg/kg/d and 45mg/ kg/d respectively.As compared to the mixed alkaloid 5L, 5n showed higher potency, stronger antitumor effect and wider antitumor spectra. It is possible that 5n is one of the main antitumoral alkaloids from Peganum harmala L. seed.更多还原