【摘要】 本文报告动物实验表明:蟾酥制剂具有增高小鼠脾脏溶血空斑形成细胞(PFC)活性率、促进巨噬细胞吞噬功能以及增高血清溶酶菌浓度等作用。此种增强 B 细胞作用,很可能是蟾酥抗炎症、抗感染以及治疗白血病、肿瘤等有效的重要机制之一。更多还原

【Abstract】 It has been reported that bufonin has anti-inflammatory,anti-infectious and some anti-leukemic effects,but its mechanism remains to be elucidated. Injection of aqueous bufonin preparation into Kunming,C57BL strain mice for 13 consecutive days has been found to increase the activity of plaque forming cells(PFC)in comparison with the control groups,indicating that it has a stimulating effect on B lymphocytes.It has no effect in vitro on E rosette forming activity for normal human lymphocytes,but an addition of 50 or 100μg of the preparation to the medium can restore rosette forming capacity of the lymphocytes inhibited by aggregated IgG,although without statistical significance.Furthermore,the preparation can stimulate in vivo the phagocytic activity of peritoneal macrophages in C57BL and IRC strain mice, as well as increase their serum lysozymes activity. These preliminary results suggest strongly that the bufonin preparation might have displayed the actions through certain immunological mechanism.更多还原