【摘要】 本文报告12名劳累性心绞痛病人,用随机单盲法比较青心酮和安慰剂对运动耐量和左心室功能的影响。在次极量踏车运动前后记录标测心电图、STI 和心阻抗微分图。结果:与安慰剂比较,青心酮使平均运动时间增加3.7分(P<0.01);标测心电图∑ST 和 NST明显减少(P<0.01);TPR 轻度降低(P<0.05)。提示:青心酮能显著改善心绞痛病人的运动耐量并降低其心肌耗氧。更多还原

【Abstract】 The effect of Qingxintong(3,4-Dihydroxyacetophenone,QXT),one of active components of Tumaodongqing (秃毛冬青,llex pubescens Hook.et Arn.Var glabra Chang)on exercise tolerance and cardiac function was compared with placebo in a randomized,single-blind study involving 12 patients with angina of effort.Multistage exercise tests(MET)were chosen and precordial ECG mapping,STI and Rheokinetocardiogram were made during MET.The results showed a greater improvement in exercise time after taking QXT than placebo with a mean rise of 3.7 minutes(P<0.01).After taking QXT,mean val ues of ∑ST and NST of ECG mapping decreased significantly compared with those after taking placebo(P<0.01).No significant differences were found in STI,SV and CO, whereas TPR descended slightly after taking QXT(P<0.05). These results suggest that QXT is useful for improving exercise tolerance and reducing myocardial oxygen demand in patients with angina of effort.更多还原