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青心酮对冠心病心绞痛病人运动标测心电图及左心室功能的影响

Abstracts of OHginal Articles Effect of Oingxintong(青心酮)on Exercise ECG Mapping and Cardiac Function in Patients with Angina of Effort

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【作者】 刘裕钊王荣金赵国璇张其吉刘玉盛王宪章麻淑清孙巧云陈可冀

【Author】 Liu Yuzhao Chen Keji Xiyuan Hospital,Academy of TCM,Beijing

【机构】 中医研究院西苑医院心血管病研究室航天医学工程研究所航天医学工程研究所 1978级研究生

【摘要】 本文报告12名劳累性心绞痛病人,用随机单盲法比较青心酮和安慰剂对运动耐量和左心室功能的影响。在次极量踏车运动前后记录标测心电图、STI 和心阻抗微分图。结果:与安慰剂比较,青心酮使平均运动时间增加3.7分(P<0.01);标测心电图∑ST 和 NST明显减少(P<0.01);TPR 轻度降低(P<0.05)。提示:青心酮能显著改善心绞痛病人的运动耐量并降低其心肌耗氧。

【Abstract】 The effect of Qingxintong(3,4-Dihydroxyacetophenone,QXT),one of active components of Tumaodongqing (秃毛冬青,llex pubescens Hook.et Arn.Var glabra Chang)on exercise tolerance and cardiac function was compared with placebo in a randomized,single-blind study involving 12 patients with angina of effort.Multistage exercise tests(MET)were chosen and precordial ECG mapping,STI and Rheokinetocardiogram were made during MET.The results showed a greater improvement in exercise time after taking QXT than placebo with a mean rise of 3.7 minutes(P<0.01).After taking QXT,mean val ues of ∑ST and NST of ECG mapping decreased significantly compared with those after taking placebo(P<0.01).No significant differences were found in STI,SV and CO, whereas TPR descended slightly after taking QXT(P<0.05). These results suggest that QXT is useful for improving exercise tolerance and reducing myocardial oxygen demand in patients with angina of effort.

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