【摘要】 大鼠肾上腺、甲状腺切除后,卵巢重量减轻,卵巢内 HCG/LH 受体功能降低。补肾中药(附子加熟地)能使上述动物卵巢增重,HCG/LH 受体功能提高。补脾中药(四君子汤)或者单用附子或熟地则无此作用。可能是补肾中药提高了卵巢对垂体促性腺激素的反应能力,从而使卵巢功能恢复。更多还原

【Abstract】 The weight of ovary and its binding capacity to ¹²⁵I-HCG of adrenalectomized adult female rats were significantly decreased as compared with the levels of sham-operation control rats.However,if the adrenalectomized rats were treated with Chinese drugs invigorating the kidney（Mankshood plus prepared Radix Rehmanniae）for five consecutive days,the weight of ovary and its binding capacity to ¹²⁵I-HCG returned nearly to the levels of sham-operation control group.If they were treated with Chinese drugs invigorating the spleen(Si Jun Zi Tang（四君子汤）no effect was observed. One month later the female rats were thyroidectomized,and those whose oxygen consumpttion was decreased by more than 30% were used for study.In these animals the weight of ovary,its specific capacity of binding ¹²⁵I- HCG,and the maximum ¹²⁵I-HCG binding（Bmax）were decreased as compared with the levels of the sham- operation control group,while the Kd value was increased.In those animals treated with Chinese drugs invigorating the kidney（Mankshood plus prepared Radix Rehmanniae,1 gm crude drug/100gm body wt.）,the weight of ovary and the specific binding capacity to ¹²⁵I-HCG increased,the Kd value decreased and the Bmax sligtly increased, therefore,the effects of thyroidectomy can be compensated. The results obtained suggested that in adrenalectomized or thyroidectomized rats the function of HCG/LH receptor in ovary was decreased,which could effect the function of sexual gland.Chinese drugs invigorating kidney could improve the function of HCG/LH receptor in ovary,thus the responsibility of ovary to gonadotrophin was increased.This problem merits further study.更多还原