【摘要】 墓头回水提物瘤内注射,对小鼠 S₁₈₀肉瘤抑瘤率达62.5%。用透射电镜观察腹腔注射,对腹水型 S₁₈₀瘤细胞有直接杀伤作用。用药动物巨噬细胞吞噬及细胞毒杀伤(¹²⁵I-UdR 释放方法)均有明显提高。以狗做亚急性毒性试验,可使白细胞增加,血小板暂时性轻度下降,肝细胞产生颗粒性变性。与厌氧棒状杆菌联合应用抗癌及杀瘤效应均提高。更多还原

【Abstract】 Development of transplanting sarcoma 180(S₁₈₀)in mice was significantly inhibited by local intralesional injection of Patrinia Scabra Bge（PSB）extract.The inhibition rate of tumor weight was 62.5%.These mice with the regression of tumor were implanted again with sarcoma cells after one and five months:none of these mice showed signs of tumor growth.Local intralesional injection was more effective than intraperitoneal injection.Significant antitumor effect was observed when the extract was combined with an immunostimulant of C.parvum. In vitro experiment showed that by peritoneal injection with the PSB extract,peritoneal macrophages were increased in the ability of phagocytosis of erythrocyte and in the effect of cytotoxic activity of S₁₈₀cell(with ¹²⁵I-UdR release assay). The acute i.p LD₅₀of PSB in mice was 0.6±0.028ml/10g,subacute toxicity in dog i.p 3- 6ml/kg of PSB once every other day for 7 times produced obvious toxic actions,including leukocytosis,temporal thrombopenia and the cloudy swelling of liver cells in the two groups. Transmission electron microscopy demonstrated that in vivo PSB-treated S₁₈₀exhibited severe alternations.The nuclear chromatin was markedly reduced and vacuoles appeared in the mitochondria in the cytoplasm.Microvilli decreased in number and size.更多还原