【摘要】 <正> 脂质体(Liposome)是磷脂类脂质在水溶液里形成的一个或多个密封的、同心圆状的微球。六十年代中期就开始把它作为生物膜的模型进行研究。七十年代初相继出现脂质体携带某些蛋白质、酶、金属螯合剂、药物等的报道,对一些遗传代谢性疾病、金属沉积中毒症、小儿呼吸危急综合症、更多还原

【Abstract】 This study is to investigate the distribution,toxicity and effectiveness of liposome-encapulated-antitumor agents （L-drugs）, such as cytoxan （L-CTX）, vincristine （L-VCR） and 5-fluorouracil （L-Fu）, as compared to free CTX, VOR and 5-Fu. The resultsare as follows: （1） The distribution of L-^99mTc and free ^99mTc: free ^99mTc appeared mainly inthe stomach, while L-^99mTc was in liver and spleen. （2） The acute LD₅₀of L-VCR and L-CTX compared to free CTX and VCR arequite different. Free VCR vs L-VCR is 1.09mg/kg: 1.70mg/kg and free CTX vsL-CTX is 316.5mg/kg: 448.3mg/kg（P<0.01）. （3） The effectiveness of L-drugs in tumor-bearing animal was compared with freedrugs: L-CTX in low dose （10mg/kg） had better antitumor effect than free CTX, but L-VCR and free VCR were about the same. It is very interesting that if free VCR wasused to treat the mice with ascitic type of liver cancer, there were only 2 mice living over30 days, a medium survival of 21.3 days （the control group was 13.9 days）, while inL-VCR group there were 5 mice living over 30 days, a medinm survival of 34.2 days（P<0.05）.更多还原