【摘要】 <正> 癌胚抗原(CEA)是一种具有人类胚胎抗原特性决定簇的糖蛋白,1965年首先由Gold等从结肠癌组织中提取,1969年Thomoson等建立放射免疫测定用于结直肠癌的诊断。此后发现CEA放射免疫测定对其它肿瘤特别是消化道肿瘤的诊断,预后判断,复发监测,疗效观察等提供了一个准更多还原

【Abstract】 The results of 1,432 cases in the determinations of serum CEA concentration, confirm-ed by clinical and pathological diagnosis,were presented. There are altogether 407 cases ofnormal controls, 294 cases of benign diseases and 731 cases of malignant diseases. In normal subjects, serum CEA concentration was less than 15ng/ml in 95.7% cases,and therefore the level of 15ng/ml was considered as the upper limit of normal value. Inthe group of benign disease, there was 41.2% cases with the serum CEA level>15ng/ml,whereas 12.2% with the level>20ng/ml. For the avoidance of overlapping, values over20ng/ml was considered as abnormal. And thus positive rate of CEA determination in thegroups of malignant liver, pancreatic lung, gastric, colorectal and mammary diseases were65%, 61.5%, 56.9%, 52.2%, 46.9% and 33.3% respectively. It was concluded that the RIA of CEA determination can be used clinically for thediagnosis of malignant diseases,especially the malignant tumors of digestive system andalso for the prediction of prognosis, evaluation of therapeutic efficiency, finding out theresidual foci and monitoring the recurrency etc. Moreover it was also a valuable tool inmany clinical research works.更多还原