【摘要】 电刺激中脑中央灰质及脑室内注射ANG Ⅱ,均不仅使血压上升,而且使猫在体灌流肾静脉血浆ANGⅡ含量增加,证明两种刺激均可通过交感神经的作用,影响肾内RAS系统促使ANGⅡ释放。本实验排除了 ANGⅡ通过血脑屏障对外周血管的直接作用。更多还原

【Abstract】 Electro-stimulation of midbrain central grey or intraventricular injection of angiotensin Ⅱ causes marked increase in release of angiotensin Ⅱ from blood-perfused kidney with an increase of systemic blood pressure in chloralosed cats. By way of kidney blood-perfusion, the possibility of direct action of angiotensin Ⅱ leaking from the ventricle through the blood brain barrier on the peripheral blood vessels was excluded. The results suggest that activation of brain angiotensin receptors with exogenic angiotensin Ⅱ or electro-stimulation of mid-brain central grey can stimulate the intrarenal renin-angiotensin system through the sympathetic nervous system to cause an increase in release of angiotensin Ⅱ from blood-perfused cat kidney.更多还原