【摘要】 以限制性内切酶及印迹杂交技术,用α-珠蛋白基因探针分析广东地区21例HbH病病人的α-珠蛋白基因在染色体上的排列,结果10例为非缺失型与α-地贫1的双重杂合子,1例为非缺失型纯合子,6例为右侧缺失型α-地贫2与α-地贫1双重杂合子,4例为左侧缺失型α-地贫2与α-地贫1双重杂合子。更多还原

【Abstract】 With restriction endonuclease mapping and blot hybridization methods, arrangements of a-globin genes in 21 patients with hemoglobin H disease in Guangdong Province were determined. Results showed that 10 cases were compounds of nondeletion gene and a-thal 1 gene (ααT/--); 1 case was a homozygote of nondeletion genes (ααT/ααT); 6 cases were compounds of rightward deletion α-thal 2 gene and a-thal 1 gene (-α/--); 4 cases were compounds of leftward deletion a-thal 2 gene and a-thal 1 gene (-α/--).更多还原