【摘要】 <正> 中分子量物质(MM)是指分子量在350—5000道尔顿间的混合物。Babb 等在观察不同血液透析条件下处理尿毒症患者过程中,认为该类物质能产生尿毒症毒性症状,从而提出了“中分子量物质”假说,目前认为,尿毒症患者中有心包炎,神经病变等并发症的出现和血浆中 MM 增高有关。由于采用一般血液透析对 MM 的清除不太理想,故有必要寻找其他治疗方法。近年来发更多还原

【Abstract】 It was proposed that middle mollecular weight compound (350-5000 daltons)may present :part of the toxic molecules responsible for uremic patients.In bilateral nephrectomy rat model, the serum middle molecules increased markedly.Agarose encapsulated charcoal (CAAC Ⅱ)as we- 11 as albumin collodion coated active charcoal (ACAC) and uncoated charcoal were used as adso- rbents during hemoperfusion.All kinds of charcoal can adsorb middle molecules both in vitro and in vivo.The CAAC Ⅱ can adsorb more middle molecules than the uncoated one,becuase the larger molecules cannot pass the encapsulated membrane of the former and spared more spa- ce for adsorbing MM.更多还原