【摘要】 <正> 硝硫氰胺(Nithiocyamine,“7505”),为一新型抗血吸虫药,由于本品难溶于水,故药代动力学的研究,受到一定限制。最近,上海医药工业研究院试制出供家畜静脉注射用的硝硫氰胺混悬剂。本文乃采用该制剂给健康家兔进行静脉注射,观察硝硫氰更多还原

【Abstract】 The pharmacokinetics of Nitrodiphenylaminoisothiocyanate（7505）in the healthy rabbits was studied.The micronized 7505 aqueous suspension was given to rabbits by intravenous injection.The plasma C-T curve indicated that the data fitted a two-compartment open model. The pharmacokinetic parameters are:t1/2α,1.253hr;t1/2β,13.509hr;K₁₂,0.258hr^-1;K₂₁, 0.214hr^-1;K₁₀,0.133hr^-1;V₁,3.687 1/kg;V₂,4.441 1/kg;V_B,9.520 1/kg;Q_B,0.488 1/kg/ hr;AUC_0-16,11.091 mg.hr/1. The mice acute LD₅₀ of micronized 7505 in aqueous suspension by intravenous or intraperitoneal injection was 169.99±13.77mg/kg（P=0.95）or 180.50±21.13mg/kg（P=0.95）respectively.It seems that the formulated dosage form given intravenusly is not more toxic significantly than given intraperitoneally.更多还原