【摘要】 嘉善县是中国大肠癌死亡率最高的地区,为了研究大肠癌高发与微量元素硒的研究,我们测定了嘉善县陶庄公社居民血硒和红细胞谷胱甘肽过氧过物酶(GSH-Px)活性。114名陶庄居民的血硒值为0.0712±0.0112μg/ml,28名健康者的红细胞GSH-Px活性为0.129±0.020A627,这些数值明显低于杭州和北京助血员,但与大肠癌和直肠息肉患者无显著差别。嘉善县、杭州市和北京市的年龄调整大肠癌死亡率与三地区健康人的血硒浓度呈负相关。更多还原

【Abstract】 Jiashan County is a district with the highest colorectal cancer mortality in China. In order to investigate the relationship between the high-risk of colorectal cancer and the trace element selenium, blood Se and erythrocyte glutathione peroxidase (GSH-Px) activities were measured in normal males and females in Teozhuang Commune of Jiashan County, Hangzhou and Beijing. in patients with colorectal cancer and those with rectal polyps. The blood Se values of 114 normal from Taozhuang were0.0712±0.0112μg/ml, and the erythrocyte GSH-Pxactivities of 28 healthy residents were 0.129±0.020 A 627. These values were significantly lower than those of the blood donors in Hangzhou and Beijing, but almost the same as those in the patients with colorectal cancer and rectal polyps. An inverse correlationship was observed between age-adjusted cancer mortalities in Jiashan County, Hangzhou and Beijing and the Se concentrations of all the blood samples collected from the healthy human donors in the above-mentioned regions.更多还原