【摘要】 木文分别在三个日本血吸虫病控制情况不同的地区:1.当年仍有血吸虫病传播;2.传播控制近l年和3。消灭钉螺达6年以上,对324倒粪检阳性的血吸虫病患者作了COP检测、Kato-Katz法粪便虫卵计数(EPG)、病史和体检。结果发现:1.COP在已控制和尚未控制或基本消灭血吸虫病的流行区,与粪检的阳性符合率都在95％以上,但反应强度差异显著。在血吸虫病未控制的地区,70％的COP阳性强度为中等(++)或强阳性(+++),而在已控制传播6年的地区,弱阳性(+)占84.8％。如以环沉率≥5％作为阳性诊断标准,则钉螺已控制或基本消灭地区,分别有43.5％及56.3％的患者漏检。2.三个地区患者粪检EPG值与COP环沉率间,都呈显著正相关。3.有、无体征患者间的COP环沉率都无显著差异。因此,COP似可用作血清流行病学调查。在接近或基本消灭血吸虫病地区,COP的阳性诊断标准似以环沉率≥1为宜。更多还原

【Abstract】 COP and fecal egg count were carried out on 324 proven cases in three endemic regions of schistosomiasis japonica of different status of snail infestation: 1. uncontrolled region, where Oncomelania is still present; 2. region of minimal transmission, where the snail has not been found for only one year; 3. controlled region, where snail has been eradicated for more than six years. The results revealed high sensitivity of COP for schistosomiasis japonica even in controlled region (97.8% positive among 46 patients) as well as in uncontrolled one (99.0% among 104) and in region of minimal transmission (96.2% among 174). But the intensity of the positive reactions was very different in the three regions, with 84.8% of the sera showing slightly reactive(+) in the controlled region, and 70% of the sera showing moderate or strong reactions (++ and +++). The intensity of infection of the patients was directly correlated with the percentage of COP egg reactivity in the three regions. It is interesting to note that the antibody level (represented by % COP egg reactivity) may decline slowly in the chronic patient even without treatment. Therefore in the controlled region, the COP egg reactivity of more than 1% might have diagnostic value for schistosomiasis.更多还原