【摘要】 <正> 中枢介质与血压调节的关系,逐步受到人们的重视。关于中枢胆硷能活动在血压调节中的作用,已经有不少研究,多数认为激活胆硷能神经元可使正常血压升高。但对于低血压时机体的代偿活动与中枢介质的关系研究较少。我们曾经在正常血压的大鼠机体看更多还原

【Abstract】 The influence of central cholinergic activity ex-erted upon the compensatory restoration of bloodpressure and presser effect of electroacupuncture(EA)under hypovolemic hypotension was studied onanesthetized rats.The results obtained were as fol-lowing:1.The spontaneous compensatory restoration ofblood pressere after hypovolemic hypotension was fa-cilitated by inhibiting the cholinesterase with theintra-cerebroventricular(icv)administration of phy-sostigmine,while it was depressed by blocking thesynthesis of acetylcholine with icv injection of Hc-3previcasly.That means the central cholinergic systemhas a tonic influence on the compensatory processof hypotension.2.The presser effect of EA under hypotensionmay be accentuated by icv administration of physo-stigmine,but it was antagonized by Hc-3 admini-stered icv previously.It suggests that the pressoreffect of EA may be partially realized through theactivation of central cholinergic system.3.The therapeutic effect of naloxone on hypo-volemic hypotension was also abolished partially byHc-3 administration.It suggests that some linkagemay exist between the cholinergic system and opiatereceptor in the central blood pressure regulatoryprocesses.更多还原