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二茂钛全氟有机酸衍生物的合成和抑瘤试验
Synthesis and Oncostatic Test of Perfluoro-organic Acid Derivatives of Titanocene
【摘要】 本文报道了一类新的二茂钛全氟有机酸衍生物的合成,并发现其中1,2,3三个二茂钛全氟二元酸衍生物,对小鼠艾氏腹水癌有明显的抗癌活性。
【Abstract】 This paper describes the synthesis of new titanocene derivatives by thereaction of titanocene dichloride and various salts of perfluoro-organic acid.Three per-fluoro-dicarboxylic acid derivatives of titanocene,(3) were obtained,which exhibit obviousanticancer activity on Ehrlich ascites carcinoma and less toxicity than the first reportedanticancer active metallocene-titanocene dichloride.
【关键词】 有机氟化合物;
有机钛化合物;
金属茂络合物;
二元羧酸;
制备;
生物活性;
抗癌药。;
【Key words】 organo-fluorine compounds; organo-titanium compounds; metallocenes; dicarboxylic acid; preparation; biological activity; anticarcinogen.;
【Key words】 organo-fluorine compounds; organo-titanium compounds; metallocenes; dicarboxylic acid; preparation; biological activity; anticarcinogen.;
- 【文献出处】 有机化学 ,Chinese Journal of Organic cHEMISTRY , 编辑部邮箱 ,1984年05期
- 【被引频次】7
- 【下载频次】37