【摘要】 本文报告多发性硬化50例,患者均有缓解复发病程。首发症状为运动无力、肢体麻木、视力障碍、共济失调步态及括约肌障碍等。临床表现提示累及脊髓者40例,视神经34例,大脑32例,脑干30例,小脑29例。脑脊液胶金曲线43例中首带型8例,中带型3例。免疫球蛋白21例中15例超过正常值。尸检2例发现有多发或散在的脱髓鞘斑块。经激素等综合治疗近期疗效有效率达94％,死亡3例。随访40例,6例死亡,23例恢复工作与学习,8例仅能自理生活,3例生活不能自理。更多还原

【Abstract】 50 cases of multiple sclerosis were reported. Remission and relapses were common andobserved in all cases. Initial symptoms were motor weakness in 17, numbness or pares-thesia 13, visual impairment in 9, ataxia gait in 8, sphincter disturbance in 6. Clinicalmanifestation in the whole course suggesting or indicating involvement of the spinal cordwere noted in 40, optic nerves in 34, cerebral in 32, brainstem in 30, and cerebellar in 29.The colloidal gold curve of CSF was abnormal in 11/43, showing a first zone curve in 8, andmidzone curve in 3. Immunoglobulin of CSF was elevated in 15/21.2 cases were examined withautopsy. The findings showed there were multiple or disseminated plaques of demyeliniation.Combined therapies with corticosteroid and others was beneficial in all cases witha near curative effect in 94％, fatal in 3 cases (6％). 40 cases were followed up for periodsvaring from 1 to 20 years and 6 months. During this time, 6 cases died. Of the remaining34, 23 were able to resume their work and study, 8 could basically take care of them-selvez, and 3 entirely depended on help from others.更多还原