【摘要】 应用吡喹酮、六氯对二甲苯及两药较小剂量联合疗法治疗华枝睾吸虫病94例,发现吡喹酮80mg/kg、120mg/kg二日疗法,六氯对二甲苯500mg/kg五日疗法以及两药较小剂量的联合疗法疗效都较满意,远期阴转率85％以上。哟喹酮60mg/kg二日疗法疗效较差,远期阴转率仅58.33％。副作用以单独应用六氯对二甲苯组比较明显;联合疗法组的尿检异常发生率较高,达48.3％。认为对轻度华枝睾吸虫病感染患者,应用吡喹酮总剂量80mg/kg二日疗法比较恰当,六氯对二甲苯只能作为次选药物。更多还原

【Abstract】 94 cases of clonorchiasis sinensis were treated with praziquantel, hexachloroparaxyleneand a combined therapy with smaller doses of both drugs above mentioned. Follow-upexamination revealed a negative conversion rate over 85％ in patients treated with praziquantelof 80mg/kg or 120mg/kg in 2 days, hexachloroparaxylene of 500mg/kg in 5 days and withthe combined therapy, but praziquantel with a dosage of 60mg/kg in 2 days revealed anegative conversion rate of 58.33％ only. The side effects of hexachloroparaxylene was moreprominent than praziquantel, and the urinalysis showed that abnomal changes occured in48.3％ of the patients with the combined therapy. Therefore, in mild infection with clonor-chiasis sinensis, praziquantel of 80mg/kg in 2 days is the regime of first choice, andhexachloroparaxylene can be considered next.更多还原