【摘要】 <正> 以辐射热-甩尾法测痛,电针小鼠“人中”、“承浆”穴,观察二价阳离子与镧系元素的相互关系,并着重比较镧系元素铽,错、EGTA、吗啡和电针镇痛的特性。实验结果表明,腹腔预先注射纳洛酮使脑室内注射Tb⁺⁺⁺、Pr⁺⁺⁺、吗啡或电针镇痛效果全部或部分对抗,此时伴有脑Ca⁺⁺水平增设;动物出现痛觉过敏。但纳洛酮处理不影响EGTA的镇痛作用和脑Ca⁺⁺水平。蛋白质合成抑制剂环己亚胺能降低Tb⁺⁺⁺和Pr⁺⁺⁺的镇痛作用,增高更多还原

【Abstract】 In the present work we have investigated the localization of the anta- gonistic effect of GABA on electroacupuncture (EA) and morphine analge- sia. EA and morphine analgesia were found to be augmented by icv inje- ction of 3-mercaptopropionic acid (3 MP, 1 μmol) which inhibited the synthesis and release of GABA but not by its intrathecal injection(5 μmol). Microinjection of 3 MP (0.4 μmol) into periaquaeductal gray (PAG) was also able to increase the EA and morphine analgesia. Muscimol (0.05 μmol), a GABA receptor agonist, and γ-vinyl GABA (0.1 μmol), an inhibitor of GABA degradation, were found to decrease EA and morphine analgesia when they were microinjected into PAG. These results indicate that GABA in PAG area may play a very important part in the antagonistic effect of GABA on EA and morphine analgesia.更多还原