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毛冬青甲素对血小板恶A2和前列环素的调节作用

The Regulating Effect of Ilexomin A on the Thromboxone A2 and Prostacyclin

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【作者】 刘法库杜金香孙颂三王科大蔺桂芬

【Author】 Liu Faku et al (Department of Pharmacology, Beijing Second Medical College)

【机构】 北京第二医学院药理教研室北京第二医学院药理教研室

【摘要】 本文主要通过血小板聚集试验,研究了毛冬青甲素的抗血栓机制。实验表明静脉注射毛冬青甲素对花生四烯酸诱导的兔血小板聚集有明显的抑制作用,阿司匹林能完全阻抑花生四烯酸引起的聚集;同时毛冬青甲素有增强大鼠动脉内皮生成前列环素的作用,而阿司匹林则无影响。提示毛冬青甲素对此物质(TXA2和PGI2)具有调节作用,伏于阿司匹林。

【Abstract】 Clinical studies show that ilexomin A is markedly effevtive in the treatment of thrombotic disease. Pharmacological experiments indicate that ilexomin A can make smaller the experimental thrombosis Now it is believed that the balance between thromboxane A2 and prostacyclin plays a very important part in regulating thrombosis. This paper studies mainly the effect of ilexomin A on the controlling factors. It has been demonstrated by our experiments that ilexomin A can inhibit platelets of rabbits from producing TXA2 and promote arteries to produce prostacyclin-like substances. Therefore, ilexomin A is a food drug for regulating the new controlling factors of thrombosis, which might be resulted from one of its anti-thrombosis mechanisms of action.

【关键词】 血小板恶A2血栓形成阿司匹林
【Key words】 Thromboxane A2ThrombosisAspirin
  • 【文献出处】 西安交通大学学报(医学版) ,Journal of Xi’an Jiaotong University (Medical Sciences) , 编辑部邮箱 ,1984年03期
  • 【被引频次】1
  • 【下载频次】57
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