【摘要】 实验证实经甲状腺片处理的家兔,耳静脉内注儿茶酚胺的剂量为50μg/Kg时,能使动物发生室颤猝死。同时,也证明室颤是上述两种激素所致心肌坏死在其发展过程中最初几分钟内出现的心肌电活动的病理性改变。室颤本身不是一种独立的病理过程。由上述两种激素构成的复合因子看来是一种内源性较强的致病因子。很可能参与人类原发性室颤的发生。更多还原

【Abstract】 Amodel of ventricular fibrillation was produced in rabbits by administering dessicated thyroid gland plus catecholamines. Dessicated thyroid was given orally with a dose of 0.25gm/kg for eight days and then 50μg/kg adrenaline or noradrenaline was injected to each rabbit.VF occured in one of five normal rabbits after intravenous NA. But the incidence of VF was highly increased in those groups injection of A or pretreated with dessicated thyroid.Four of five occured VF. The difference was significant. The result demonstrated that the arrhythmic effect of catecholamines on the cardiac muscle can be highly potentiated by an excess of thyroid hormone.It indicated that VF was a form of pathologic electric activity appeared several minutes after development of cardiac necrosis induced by the above mentioned 2 hormones, rather than a specificpathologic process. The complex factor composed by these hormones seems to be a rather strong endogenic pathogenic factor. This may participate in precipitating human primary VF.更多还原