【摘要】 本文用免疫细胞化学方法研究了局麻下三叉神经半月神经节神经元内P物质的变化。结果表明,局麻侧面部皮肤P物质阳性神经纤维增多,半月神经节内P物质阳性的中小型细胞减少,三叉神经脊束核末梢内P物质阳性反应减弱。对照侧相反。结果提示局麻药阻断了钠离子内流,使神经节细胞轴浆运输减慢,P物质在周围突的储留增多,胞体P物质合成及中枢突释放均减少,痛信息不易传入中枢而镇痛。更多还原

【Abstract】 The changes of substance P-positive reaction in the neurons and their process of semilunar ganglion of the rat under local anesthesia have been studied by immunocy-tochemical (PAP) method. The results showed that in the local anesthesia side the substance P-positive nerve fibers in the corresponding facial skin were increased, the number of substance P-positive medium and small neurons in the semilunar ganglion was decreased and the substance P-positive reaction in the terminals of the nucleus spinalis nervi trigemini was weakened. Whereas in the control side the changes turned out contrary to that in the anesthesia side. These findings suggest that the local anesthesia drug blocked the inflow of sodium ions, therefore, slowing down the axoplas-mic transport of the semilunar ganglion neurons and increasing the amount of substance P storing in their peripheral process, decreasing substance P synthesized in the perikaryon and its release from the central process of the semilunar ganglion neurons. By this way, pain informations could not be conducted to the central nervous system and an analgesia effect would be led to.更多还原