【摘要】 对45例流行性出血热患者,检测血小板计数及聚集功能(比浊法)。发热期患者中重型19例、中型13例、轻型13例,血小板计数小于5万/mm~3者各有13例、3例、6例;聚集功能低于10％者各为16例、9例、6例,占69％。血小板功能障碍,随病程进展而加重,且与肾功能损害有关。随疾病的好转,血小板计数与功能也逐渐恢复正常。22例发热期患者作血小板涂片,用间接荧光染色检测表面免疫复合物,有10例荧光染色阳性。用封闭试验证实其有特异性。更多还原

【Abstract】 Blood platelets aggregation function was studied in 45 cases of epidemic hemorrhagic fever, and specific Ag-Ab complexes were examined in 22 cases. During the early febrile stage, platelets count decreased to<50, 000/cmm in 22 cases (48.3%), and percentage of aggregation was <10% (normal 53±7.9%)in 31 cases (69%). The decrease was significant in seriously ill patients. This might explain the severe bleeding in febrile stage. The aggregation function was further impaired as the disease progressed to shock and oliguric stages. In polyuric and recovery stages, the function tended towards normal. Specific Ag-Ab complexes were demonstrated on the surface of platelets in platelet smears in 10 out of 22 cases.更多还原