【摘要】 5例复发后耐药性的晚期淋巴瘤,其中何杰金病1例,非何杰金淋巴瘤4例,分期Ⅲ_B 1例,Ⅳ_B 4例。骨髓涂片及活检均示造血功能正常,未见淋巴瘤细胞浸润。采用一次性大剂量环磷酰胺化疗和全淋巴结以及累及脏器的⁶⁰钴照射,并结合自身骨髓移植治疗（简称 ABMT-CI）。ABMT-CI 后48小时,患者肿大的淋巴结开始缩小,至第3～4周有3例获得完全缓解,2例部分缓解;缓解时间1～9个月。其中2例至今仍处于缓解状态。外周血白细胞治疗后第9天下降最低（66～2,000/mm³）、血小板在第17天最低（6～4万）。一个月后血象及免疫功能基本恢复正常。实践证明 ABMT-CI 方案具有疗程短、见效快、作用较强而副反应可耐受的特点,为复发后耐药性的晚期淋巴瘤提供了再次缓解机会。更多还原

【Abstract】 Five patients with advanced lymphoma refractory to conventional therapy were treated by one dose cyclophosphamide,total nodal irradiation and autologous bone marrow transplantation(ABMT-CI).Smears and biopsies of bone marrow became normal in 4 wk in all the cases with no evidence of infiltration.After 48 hr of ABMT-CI treatment,the enlarged nodes began to shrink.Three patients had complete remission,while the other two showed partial remission at 3rd and 4th wk.No evidence of relapse was observed in 1-9 mo.White blood cells count in the patients decreased to 66-2,000/cmm at 9 th day.Platelets count reached to lowest values 6,000-40,000/cmm at 17th day. Peripheral blood counts and immunological functions became normal in all cases after one too.These results of ABMT-CI show that it is a simple therapeutic procedure, with rapid response and tolerable side reaction.更多还原