【摘要】 作者以6条狗为感染性休克模型,观察了感染性休克时红细胞内外钠离子浓度的变化。实验表明严重感染后钠离子进入细胞,造成血清低钠。钠离子分布异常与低血压有关。钠离子转移反映了细胞受损。红细胞内钠离子浓度的升高至感染末期时方有显著意义,提示红细胞作为细胞损伤的模型不够敏感。更多还原

【Abstract】 In this study, the flux of sodium in red cells and serum was investigated in 6 conscious dogs subjected to septic shock. With severe sepsis, sodium entered cells and led to hyponatremia. It was found that the mean aortic pressure (MAP) was positively correlated with serum Na~+ (P<0.01) and negatively correlated with RBC Na~+ (P<0.01) and RBC Na~+/serum Na~+ ratio (P<0.01). However, only when MAP dropped more than 30% was RBC Na~+ increased to significant levels, and the increase in RBC Na~+/serum Na~+ ratio was significant after 19% drop in MAP. Since significant elevation of red cell sodium occurred only during terminal sepsis, it is felt the red cell is not an ideal model for the damaged cells.更多还原