【摘要】 ^99m锝-甲溴苯宁（Mebrofenin）被认为是当前最优良的一种肝胆显像剂,作者参考有关文献后,进行试制获得成功,经初步动物实验,证实该显像剂能使肝胆清楚显像,值得今后在临床上试用。更多还原

【Abstract】 Mebrofenin was synthesized by nitration of mesitylene, followed by reduction, bromination and acylation with nitrilotriacetic acid. The 99mTc-complex of this compound was prepared by stannous chloride reduction of sodium pertechnetate in aqueous solution of the appropriate compound. 99mTc-Mebrofenin possesed high hepatic specificity and rapid hepatocellular transit; it was also resistant to competition for hepatobiliary excretion from bilirubin and rapid radiolabeling with high radiochemical purity and stability. 18 cases of patients were studied by this agent, all obtained excellent results.更多还原