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血浆粘度六因素线性逐步回归分析

LINEAR PROGRESSIVE REGRESSION FOR PLASMA VISCOSITY TO ITS SIX FACTORS

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【作者】 施永德唐镇生肖保国钱建国罗志特范祖霖丁德明

【Author】 SHI YONGDE(Department of Biophysics, Faculty of Basic Medical Sciences, Shanghai First Medical College, Shanghai)TANG ZHENGSHEN, XIAO BAOGUO, CHIEN JIANGUO(Department of Neurology and Radiology, Hua shan Hospital, Shanghai First Medical College, Shanghai)LUO ZHITE, FAN ZULIN, DING DEMIN(Shanghai Scientific and Technical College, Shanghai)

【机构】 上海第一医学院基础医学部生物物理学教研室上海第一医学院华山医院神经病学教研室上海第一医学院华山医院放射科上海科技大学上海科技大学

【摘要】 本文对39例对象的血浆粘度(Y)及其六个血浆成分——白蛋白(x1)、球蛋白(x2),纤维蛋白原(x3)、胆固醇(x4)、甘油三酯(x5)和β脂蛋白(x6)进行了测定,并对Y和x1~x6进行了六元回归,还对这六个因子产生血浆粘度的贡献作了排列,依次为x2→x3→x6→x4→x5→x1。继之以不同的F值的界限,进行了逐步回归,选取其主要因子和剔除其次要因子,从其复相关系数、标准估计误差、方差分析并在实际应用中加以检验,最后获得的三元方程式:Y=0.59453+3.23404·10-4x2+5.15788·10-4x3+5.14465.10-4x6是与实际相符合的较为理想的方程式。这一方程在理论上反映了与血浆粘度形成有关的主要化学成分,以及粘度与其主要化学成分间的定量关系;在临床上对于诊治高粘血浆症有一定的指导意义。

【Abstract】 In this study,determinations of plasma viscosity(Y)and its 6 chemical factors --x1 albumin, x2 globulin, x3 fibrinogen, x4 cholesterol, x5 triglyceride and x6 beta-lipo-protein were carried out in 39 subjects. Linear regression equation aswas made. The contributions of these factors to viscosity were foundin order of x2→x3→x6→x4→x5→x1. Then the progressive regressions were done at different levels of F, the main factors being chosen and the minor ones d iscarded. On verification by the coefficient of multiple correlation, standard error of estimate, analysis of variance and its application, to practice, the equation was proved to be satisfactory, for it was found to coincide with actual condition as Y=0.59453+3.23404·10-4 x2+ 5.15788·10-4 x3 + 5.14465·10-4 x6. Theoretically, the above equation showed the intrinsic relation between viscosity and the main factors, and clinically it seemed to be of great help to the diagnosis and treatment of high plasma viscosity syndrome.

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