【摘要】 <正> 肝性甘油三酯脂酶分布在肝窦内皮细胞表面,故又称肝内皮细胞脂酶(HEL)。已证实肝素可使大鼠的HEL释放。Nikkila和Kuusi等研究指出HEL对高密度脂蛋白-胆固醇(HDL-c)的清除起重要作用,是HDL分解代谢的关键酶。为了深入了解胰岛素对脂质代谢的影响,我们研究了胰岛素对正常大鼠HEL活性的影响。实验动物为200～250g正常雄性大鼠。更多还原

【Abstract】 In the control and insulin-treated groups(dose,1.86μ/Kg.B.W./day×14days,subcutaneously),the plasma heparin-releasable hepatic endothelial lipase(HEL) activities are 2.65±0.86 and 3.81±1.15μmol FFA/ml plasma/hr((?)±SD)respectively,the heparin-releasable HEL activities of isolated liver perfusate are6.25±2.29 and 10.82±2.80μmol FFA/g.liver/hr((?)±SD) respectively.Thedifferences are significant(P<0.02,P<0.002).These results suggest that insulin may activate HEL.更多还原