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肿瘤病人及正常人外周血大颗粒淋巴细胞的观察

OBSERVATIONS ON LGL CELLS IN PERIPHERAL BLOOD OF TUMOR PATIENTS AND NORMAL INDIVIDUALS

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【作者】 王长安徐文玉张冬青臧人杰楼鼎秀候国英

【Author】 Wang Chang-an Shanghai Institute of Immunology, Rui Jin Hospital, Shanghai Secend Medical College

【机构】 上海市免疫学研究所基础免疫研究室上海第二医学院附属瑞金医院内科实验室上海第二医学院附属瑞金医院内科实验室

【摘要】 本文报道了LGL细胞在肿瘤病人外周血中的数量;与治疗有关的动态变化及正常人LGL细胞与NK活性的关系。发现除了LGL细胞具有颗粒外,少数小淋巴细胞浆内也具有颗粒。19例癌症治疗好转病人LGL细胞百分数较正常人为高。18例癌症恢复健康病人LGL细胞百分数与正常人相比无明显差异。5例脑肿瘤手术后及9例肝癌住院治疗病人LGL细胞升高。20例正常人LGL数量与NK活性之间有平行关系。

【Abstract】 This article describes the amount of LGL cells in the peripheral blood of tumor patients, the kinetic changes relating to therapy, and the relevance of LGL cells in normal individuals to the NK activity.In addition to granules in LGL cells, this study reports some small lymphocytes having granules in their cytoplasms. It is reported that the amount of LGL cells in cancer patients is more than those in normal individuals. The amount of LGL cells % in 19 cancer cases that show good therapeutic effects has been found to be bigger than that in both normal individuals and cancer patients. The LGL cells % in 18 recovering cancer cases was not significantly different as compared with healthy individuals. The LGL cells in 5 cases with cerebrum tumor after operation were elevated, and so were those in 10 cases with liver carcinoma for therapy in hospital. In 20 normal individuals, the relevance of the amount of LGL cells was in parallel to the NK activity.

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