【摘要】 本文报道应用酶联免疫抑制法对111例肾脏及泌尿道疾病进行尿β₂微球蛋白测定,并与常规肾功能试验对照比较,并初步探讨了该项检查的临床意义。更多还原

【Abstract】 Application of inhibited enzyme immunoassay to determine urine β2micro globulin (β2m) in 111 cases with renal and urinary tract disorders is presented. It is also compared with conventional renal function tests.The positive rate of urine β2m in 27 patients with chronic renal failure was 85.18%, it was significantly correlated with BUN, Scr and Ccr. Urine β2m was positive in 2 acute renal failure patients, and it varies as the disease develop. 1 case of renal tubular acidosis was also positive. 6 of 7 SLE nephritis were positive (approximately 85.71%). In chronic nephritis (common type), acute nephritis, nephrotic syndrome and urinary tract diseases, only few individual cases were positive, therefore, there was no statistical significance.The positive urine β2m was mainly related to the defect in renal tubular transporting functions. In addition, if serum β2m exceeded the transporting ability of renal tubule, it was excreted in the urine.Thus, the determination of urine β2m was a sensitive index in detecting renal tubular function and it was also a reference index in chronic renal failure.更多还原