【摘要】 本文用¹²⁵IUdR 标记的K 562细胞作为靶细胞,检测 29例病毒性乙型肝炎患者（急性期17例、慢迁肝7例、无症状 HBsAg 携带者3例和肝硬化2例）外周血中自然杀伤（NK）细胞的活性。结果发现40例正常对照组的NK活性平均值±SD 为35.24±12.24％;5例急性早期患者显著升高（P<0.001）;7例慢迁肝患者明显降低（P<0.05）;9例恢复期和 3例无症状 HBsAg携带者均在正常范围内。以上结果与中岛悦朗和Serdengerti的报道相符,但与另些作者的资料有差异。我们认为NK活性在病程初期升高和在慢性期降低与干扰素的生成和乙肝病人早期肝损害有关,与若干种其他病毒性疾病中所见的规律相仿。更多还原

【Abstract】 Using 125I-UdR labelled K 562 cells as target cell for assaying NK activity in peripheral blood from 29 cases of viral hepatitis B, acute hepatitis 17, chronic persistent hepatitis 9, asymptomatic HBsAg carriers 3 and cirrhosis of liver 2, together with 40 healthyadults as controls. The following results were obtained:mean ± SD of NK activity of the control group was 35.24 ±12.24%; found to be markedly elevated in 5 early acute hepatitis cases (P< 0.001), significantly depressed in 7 chronic persistent hepatitis and 2 cirrhosis of liver patients (P<0.05), while that of 3 carriers and of 9 convalescents were within normal range. The above results consistent well with the reports of some authors, but not with some of the others. According to our observation the early rise of NK activity in acute infection and the declination in chronic stage was in accordance with the blood interferon level as was observed in some other viral diseases, (e. g. CMV, LCM et al), and also it was in parallel with SGPT level in early stage of acute hepatitis B.更多还原