【摘要】 为了从围产期角度观察出生前后游离氨基酸的发育动态变化并为临床提供必要生理参考值,本文根据围产期不同阶段分别测定了出生前妊娠中期及晚期的羊水(9例及11例)、出生时脐血(代表胎儿)及孕母血清(26例及30例)、出生后3个不同年龄组儿童血清(分别为24、30及35例)中的游离氨基酸值。结果表明:(1)中期妊娠羊水中大多数氨基酸高于晚期妊娠羊水,但羊水值又普遍低于脐血及孕母血清值;(2)脐血游离氨基酸值低于相应孕母值;(3)新生组大多数氨基酸值明显高于婴幼儿组,但是学龄期时又趋回升并接近新生儿组值,作者对上述观察结果作了讨论,并强调了提供这些游离氨基酸生理值对临床实践的必要性。更多还原

【Abstract】 To observe the prenatal and postnatal development of free amino-acid metabolism in the field of perinatology, we have respectively determined the physiological concentration of free amino-acids in amniotic fluid taken from pregnant women during early and late gestation, in maternal and cord (fetal) sera at parturition, and in sera taken after birth (including normal newborn, infancy and school children groups) according to the consecutive stages of perinatal course. The results obtained indicate that: (1) most of amino-acids in amniotic fluid during early pregnancy appear to be higher than those during late pregnancy, whereas the concentrations of most of amino-acids in amniotic fluid are found, in contrary, to be lower than these in maternal and cord sera; (2) the concentrations of amino-acids in cord sera are higher than those obtained in maternal sera; (3) the concentrations of most of amino-acids in the newborn group seem evidently higher than those observed in the infancy group, then, the corresponding levels tend to return in school-children group, but still below the data obtained in the newborn group.更多还原