【摘要】 <正> 据1943年Robinson报告,用荧光染料可辅助内窥镜检查诊断,但直至1975年胜建一等在日本第17届内窥镜学会总会上才第一次报告了其临床应用。此后日本陆续有更多还原

【Abstract】 Since 1982, we have screened a series of Chinese traditional and western drugs of non-hemafoporphyric nature by means of fluorospectrometric methods, in order to select fluorescent substances most suitable for the detection of gastric cancer by fluorescence endoscopy.Fluorescein sodium is the first substance used in a group of 34 cases, including 13 gastric cancers, 12 ’precancerous’ lesions and 9 cases with benign gastric diseases. After a quick initial endoscopic examination, 5ml of 10% fluorescein sodium was injected rapidly into the patient’s vein, and the color changes of the gastric mucosa was observed while exposing to an exciting light coming from a cold light source with a special blue filter to emit a light with a wavelength of 52Onm.In about 5 minutes, an intense fluorescence appeared over the areas of gastric cancer (92.3%) and precancerous lesions (92%) while no fluorescence could be seen over those of normal gastric mucosa and gastric benign diseases. A marked fluorescence peak was also shown by the fluorospectromctry in gastric cancer (91.7%)and precancerous lesions (90.5%) but no fluorescence peak in normal gastric mucosa and gastric benign lesions.For this reason, the authors consider that it is a simple, safe and effective diagnostic method, and may bc used in out-patients as a useful tool for the diagnosis of gastric cancer.更多还原