【摘要】 本文测定了五类实验性高血压大鼠三个脑区中二种脑啡肽的含量。在两肾两夹及两肾“8”结扎—盐高血压大限脑干,下丘和纹状体中甲脑啡肽(MEK)和亮脑啡肽(LEK)含量显著高于正常大鼠。在一肾一夹大鼠中除纹状体MEK及下丘LEK增加外,EK含量无显著变化。在两肾“8”结扎大鼠中仅脑干MEK稍有增加。DOCA—盐高血压大鼠与上述几种大鼠不同,它们的脑干和纹状体中EK含量虽然增加,而下丘MEK却明显下降,DOCA—盐大鼠中的这些变化随DOCA—盐处理时间延长而变得更加显著。结果提示以水纳潴留为特征的高血压动物中涉及中枢EK的含量改变。此外,DOCA对下丘MEK含量可能有重要作用。更多还原

【Abstract】 The contents of two kinds of enkephalin (EK) in three cerebral regions were measured by using radioimmunoassay method in five types of experimental hypertensive rats. In the "two-kidney two-clip" group and "two-kidney ’8’-ligated-salt" group, methionine-EK (MEK) and leucine-EK (LEK) concentrations in the brain stem, hypothalamus and striatum were significantly higher than in those regions of the normal rats. However, in the "one-kidney one-clip" rats, except for an incressc of MEK in the striatum and LEK in the hypothalamus, the contents of EK had no significant chages. In the "two-kidney ’8’-ligated" rats, the contents of MEK in the brain stem were somewhat decreased. Nevertheless, in the "DOCA-salt" hypertensive rats, MEK and LEK in the brain stem and the striatum were increased, whereas MEK in the hypothalamus were markedly decreased. These changes in DOCA-salt rats became more significant along with the duration of DOCA-salt administration. The results suggest that central EK is implicated in the course of hypertension characterized by sodium and water retention. Besides, DOCA may have an important effect on the contents of MEK in the hypothalamus.更多还原