【摘要】 以酚红血浓度变化为指标,比较经不同时间不同剂量包甲素组与正常对照组及肾损害组所引起的酚红药代动力学参数的差别。结果提示用包甲素后10分钟组对酚红参数的影响大于5小时组。更多还原

【Abstract】 32 rabbits were used to study the effect of Baogongteng-A (BA) on renal function. The animals were divided into four groups, 8 rabbits each. Grup Ⅰ was the control, Group Ⅱ and Ⅲ were pretreated with BA 25μg/kg and 50μtg/kg, 10 minutes and 5 hours before PSP injection respectively. Group Ⅳ was subjected to renal damage induced by mercuric chloride. PSP 0.6% 0.2ml/kg was given intravenously to each animal. Pharmacokinetic parameters of PSP were calculated to estimate the renal function. The results showed that the values of clearance and AUC in Group Ⅱ were lower than those in Group Ⅰ. But in Group Ⅲ, they were very close to those of the control. As far as these parameters were concerned, there was a statistically significant difference between Group Ⅲ and Group Ⅳ. Whether the effect of BA on renal function is caused by direct or indirect action cannot be identified in this present expmerient. Its elucidation requires further studies.更多还原