【摘要】 天然除虫菊素和人工合成的拟除虫菊酯是一类高效、低毒的杀虫剂。它们的化学结构,特别是立体构型对其生物学活性具有决定性的影响。 本文综述除虫菊农药的绝对构型与生物学活性之间的关系,测定和拆分除虫菊农药几何异构体和光学异构体的方法,除虫菊农药酶代谢的动力学机制,并讨论了化学合成立体特异性高效除虫菊酯的可能性。 文中所述测定和拆分除虫菊农药的色谱方法具有样品用量少、拆分效率高和分离产物纯等优点。更多还原

【Abstract】 The natural insecticidal pyrethrins and synthetic pyrethroid erters are powerful insecticides. The potencies of pyrethroids are very sensitive to the structure and chirality of the acidic and alcoholic components. This paper reviews the relationships between biological activity and absolute comformation of pyrethroids, the methods of analysis and separation of geometric and optical isomers, the kinetic mechanism of metabolism of pyrethroid stereoisomers, and finally discusses how to synthesize the stereospecific pyrethroids.The chromatographic methods for analysis and separation of stereoisomer of pyrethroids offer distinct advantages, such as small sample size,and high resolution for maderatescale separations and final products.更多还原