【摘要】 本文评价了阉割及注射外源性雄激素对雄性小白鼠的胸腺组织,外周血淋巴细胞,以及腹腔巨噬细胞吞噬功能的影响。结果证明:阉割小鼠胸腺的重量明显增加,外周血淋巴细胞中ANAE(+)细胞百分率显著增高,以及巨噬细胞的吞噬功能也明显增强;注射丙酸睾丸酮(50微克/天,前10天每天肌注一次,后10天隔日肌注一次)的小鼠导致胸腺缩小和外周血淋巴细胞中ANAE(+)细胞百分率明显降低。提示睾丸摘除可提高细胞一介导免疫;而注射外源性雄激素则引起抑制效应。更多还原

【Abstract】 This study evaluated the effect ofcastration and exogenous androgen on the thymic tissue, the peripheral blood lymphocytes and the phagocytic function of peritoneal macrophages in male mice. It was found that in the castrated mice the weight of thymus increased significantly, the precentage of ANAE(+)cells in peripheral blood lymphocytes was markedly increased and the phagocytic function of macrophages was also signigicantly increased. In the mice injected with testosterone propionate 50μg/mouse/day, for 20 days i.m.(q.d.in the first ten days, q. o. d. in the second ten days), the thymus appeared atrophic and the percentage of ANAE(+)cells in peripheral blood lymphocytes was significantly decreased. These results suggest that orchidectomy may enhance cellmediated im munity whereas injection of exogenous androgen has suppressive effect.更多还原