【摘要】 本文以实验形态学方法研究雌二醇（Es₂）诱发的Swiss小鼠胸腺退化及其机理。实验结果表明,摘除卵巢可使正在退化的胸腺增生;注射Es₂于未成熟小鼠,胸腺不仅停止生长,而且明显退化;注射Es₂于经氢化考的松（HC）诱发胸腺退化的小鼠,则能阻遏胸腺再生。这些结果证实,Es₂对胸腺具有明显的抑制与致退化作用。Es₂与HC致胸腺退化的方式不同,Es₂在体内、体外对胸腺细胞均无致死作用,而是缓慢降低胸腺细胞增殖率,使胸腺缓慢退化。注射Es₂后,未见小鼠肾上腺发生重量与结构的明显改变。Es₂对摘除肾上腺的小鼠亦诱发其胸腺退化。这表明,Es₂的致胸腺退化作用是非肾上腺依赖性的。注射Es₂后,胸腺激素生成功能活跃的Ⅰ型胸腺上皮细胞数量减少,上皮细胞结构变性。从而提示,Es₂可能引起胸腺上皮细胞的激素分泌功能发生某种改变或衰退,继而导致胸腺细胞增殖活性降低,胸腺退化。更多还原

【Abstract】 The involution of female Swiss mouse thymus induced by estradiol （Es₂） were studied by morphological methods.The involuting thymuses of 2-month-old mice increased greatly in weight after ovariectomy. Treated with Es₂, the thymuses of immature mice not only stopped growing, and also involuted apparently. The regeneration of thymuses was impeded in the mice whose thymuses had already involuted induced by hydrocortisone when treated with Es₂. These results proved the obvious inhibiting and involution-inducing effects of Es₂ on thymus. The pattern of the thymus involution induced by Es₂ was different from that by hydrocortisone. Es₂ had no lethal effect on thymocytes either in vivo or in vitro, but it reduced the proliferative rate of thymocytes slowly and caused the thymus involution gradually. Es₂ made no remarkable changes in weight and histology of adrenal glands. Thymus involution induced by Es₂ was also detected in adrenalectomized mice. These results indicated that thymus involution induced by Es₂ was adrenal independent. Accompanying the thymus involution, the number of type Ⅰ thymic epithelial cells decreased, which were considered to produce thymic hormones actively, and the structure of thymic epithelial cells denatured. These morphological degenerative alterations suggest that Es₂ can result in some changes or decline of the hormone secretory activity of thymic epithelial cells, and then the proliferation of thymocytes will reduce and thymus involution will take place.更多还原