【摘要】 本文目的是检查可移植性子宫颈癌(U27),经二十多年传代后形态的改变特征及其侵袭能力。组织学和透射电镜检查证明本瘤株已变为低分化的上皮癌;电镜检查胞浆内仅查见少数张力原纤维,细胞连接仅见半桥粒及类桥样结构,未见典型鳞状上皮癌的特征。扫描电镜检查可见癌细胞表面有两种主要表现类型:一种带有大量微绒毛;另一种表面比较光滑仅有少量泡状突起。肌肉内小块移植后3天,即见大量癌细胞脱离癌实体,向肌肉纤维之间活跃侵袭,侵袭方式主要沿肌细胞之间的自然间隙连续侵入,也见沿肌细胞表面呈阿米巴样运动,有的癌细胞表面伸出不同突起与靶细胞直接连接,有的癌细胞伸出丝状伪足,用其分叉的末端紧紧抓住靶细胞表面。在癌组织侵袭之处可见肌细胞变性、进而萎缩,最终可完全被癌细胞所代替。更多还原

【Abstract】 The purpose of the present experiment was to observe the morphological characteristics and invasiveness of a transplantable cancer NO 27 (U 27) after serial passages about 20 years. The results were as follows: The morphological characteristics of this tumor strain was low-differentiated carcinoma which were demonstrated by light microscopy and transmission electron microscopy. In the cytoplasm the single irregular distribution of the tensile fibrils and some semi-desmosome between adjacent cells were discovered by transmission electron microscopy. Two types of cancer cells were observed on the surface of the cancer nest by scanning electron microcopy:Ⅰ), There were many microvilli on the surface of the first type cancer cells; 2). The surface of the cancer cells of the second type were more flat sometimes with single small blebs. Many cancer cells had been released from cancer cell clump after 3 days of intramuscular implantation. Later they actively invaded into the spaces between muscle fibers in the form of amebae. Some cancer cells stretched out their filopodia directly in contact with target cells. The degenerative and atrophic changes of muscle tissue appeared in the invasive area of cancer cells. Finally these changes were leading to the disappearance of the entire structure of the muscle with the replacement by cancer tissues.更多还原