【摘要】 <正> 我们自1973年以来曾用克山病病区与非病区出产的粮食对大鼠进行多次饲养观察。结果均表明,病区饲料组检出心肌实质性病变,生长迟缓,平均存活日数少,心脏重量相对增大,胸腺及褐脂重量较低,对一些牵累因子耐受性差,机体对某些微量元素示踪代谢的吸收率较高。病区饲料组大鼠与非病区饲料组大鼠之间存在明显差异。实验证明,病区粮中存在致动物心肌坏死和影响生长因子。为了进一步探讨病因,我们拟对此种差异的发病机理首先进行研究。鉴于近来大量资料证明cAMP 是机体组织内的一种重要活性物更多还原

【Abstract】 The present experiment studied the albino rats fed on corns from endemic andnon-endemic areas of Keshan disease,not only their nutrition and development wereobserved but also the cAMP contents in organs and tissues was determined by competi-tive protein binding assay.The experiment consisted of two parts:Part A and part B.Results of Part A and B revealed:the body weights of animals fed on corns from ende-mic areas were prominently lower than that fed on corns from non-endemic areas.The gradients of cAMP contents in various tissues in two experimental partswere the same.The cAMP contents in tissues were lower in endemic group than innon endemic group.The cAMP contents in various tissues of animals fed on cornsfrom endemic areas of Keshan disease,was significantly lower than that ofanimals fed on corns from non-endemic areas.It revealed that there might be a factor which influence the animal nutrition in the corns from endemic areas.更多还原