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乌头碱中毒所致心律失常20例抢救体会

Therapeutic experience of cardiac arrhythmia in 20 cases after aconitine poisoning

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【作者】 窦桂芳; 范继英;

【Author】 Dou Guifang;Fan Jiying Department of Internal Medicine, The First Affiliated Hospital, Henan Medical College

【机构】 河南医学院一附院内科; 河南医学院一附院内科;

【摘要】 本文报道了我院于1966年11月~1983年4月共抢救乌头碱中毒所致各种心律失常20例,全部治愈,无1例死亡,抢救方法如下: 1.立即洗胃,导泻及大量静脉输液,以加速毒物从体内排泄。2.在无特殊拮抗剂的情况下,乌头碱中毒所引起的各种缓慢型心律失常,主要为迷走神经强烈兴奋所致,应选用阿托品,以阻断迷走神经对窦房结及房室结兴奋性的抑制。对于窦房结功能低下而出现的室性心律失常,应用阿托品亦可使其消失。3.患者若出现呼吸抑制,休克或心脏停搏者,均提示中毒严重,应紧急治疗。4.室性心律失常,应立即静脉注射利多卡因。5.乌头碱中毒在体内无蓄积作用,如用阿托品治疗,心律失常消失后,即可停用,以免发生中毒。

【Abstract】 A series of 20 cases with cardiac arrhythmias due to aconitine poisoning d-uring the period of 17 years(Nov. 1966--April. 1983)all recovered. The following methods were employed for these cases. 1. An emergency gastric lavage, a catharsis and intravenous supply ofa large amount of liduid were carried out in order to accelerate eliminationof aconitine from the body. 2. Under the condition of no specific antidote, bradycardia caused byaconitine poisoning chiefly results from its strong stimulation of the vagusAtropine is indicated for the treatment of bradycardia to get rid of the de-pression that comes from sinus and atrioventricular node. It is also indica-ted for ventricular arrhythmia secondary to dysfunction of sinus node. 3. The complications of depressed respiration, shock and ventricularstandstill demonstrate the severity of poisoning. Effective treatment mustbe taken. 4. Ventricular tachycardia is an emergency indication to give lidocaineintravenously. 5. Aconitine does not accumulate in the human body. As soon as arrh-ythmias disappears atropine should be discontinued in order to prevent ove-rdose.

【关键词】 乌头碱; 心律失常; 中毒;
【Key words】 aconitine; arrhythmia; poisoning;
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