【摘要】 以大肠杆菌内毒素粗制品注入狗与兔静脉内引起DIC,同时出现血浆血红蛋白增高。由于血浆血红蛋白含量异常率仅次于血小板变化,在异常率较高的指标中以血浆血红蛋白含量变化比值最大,并且内毒素所致DIC动物死亡率与血浆血红蛋白含量成正比,因此血浆血红蛋白可能成为内毒素所致DIC的辅助诊断与预后判断的指标之一。更多还原

【Abstract】 The experiments were performed on 14 dc.gs and 11 rabbits anesthetized with sodium pentothal to determine the relationship between plasma hemoglobin(PHb) and disseminated intravascular coagulation (DIC) induced by endotoxin (ET) in dose of LD750 After ET injection platelet, plasma fibrinogen, prothrombin time, serum fibrin(ogen) degradation products and plasma protamine paracoagulation test showed the changes of DIC. PHb concentration elevated markedly at the same time. The changes of PHb was the second in order of abnormality percentage and the first according to the change ratio. Thus the determination of PHb concentration can serve as a supplementary index for DIC diagnosis. The fact that there was only an intermediate negative correlation between PHb and platelet count and fibrinogen concentration shows that microangiopathy hemolysis associated with DIC is one of the causes of the increase in PHb concentration and suggests that the impairment of unit membrane may also contribute to the changes of PHb concentration. As the mortality of the animals with DIC is in direct proportion to PHb concentration, it is possible that PHb concentration is regarded as an index to evaluate the severity and the prognosis of ET-induced DIC.更多还原