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二亚硝基哌嗪对大鼠鼻咽鳞状上皮更新的影响

RENEWAL OF NASOPHARYNGEAL SQUAMOUS EPITHELIUM OF RATS TREATED WITH N,N-DINITROSOPIPERAZINE

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【作者】 陈主初; 潘世宬; 孙去病; 姚开泰;

【Author】 Chen Zhuchu Pan Shicheng Sun Qubing Yao KaitaiCancer Rescach Laboratory, Hunan Medical College

【机构】 湖南医学院肿瘤研究室; 湖南医学院肿瘤研究室;

【摘要】 本文用放射自显影术对正常大鼠以及二亚硝基哌嗪(简称二亚)处理鼠诱癌过程中鼻咽鳞状上皮细胞的更新进行了观察。实验表明,正常情况下,大鼠鼻咽底壁鳞状上皮细胞移动的变化是“S”形曲线,其方程式为 y=ap0/bp0+(a-bp0)e-a(x/72);二亚处理后,大鼠鼻咽底壁鳞状上皮细胞移动表现为抛物线,其方程式为 y=a+bx+cx2。同时对食道、颊部粘膜的细胞移动进行了观察。

【Abstract】 The migration of cells of the nasopharyngeal stratified squamous epithelium was investigated radioautographically in the normal and DNP-treated rats at various intervals after a single injection of thymidine-3H. The results showed that: (1) in normal animals, the pattern of squamous cell migration in the nasopharyngeal ventral wall appeared a sigmoid curve; (2) The cellular renewal was changed in the nasopharynx after DNP treatment in all rats, the migration of squamous cells appeared a parabolic curve. (3) The cell migration of the esophagus and bucca cavioris was not changed in the control and DNP-treated rats. It seems that the change of the cellular migration in the nasopharynx may be related to the effect of DNP.

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