【摘要】 本实验用家兔左室支动脉两次结扎模型及心外膜电图标测方法评价人参总皂甙的抗心肌缺血作用。结果表明,人参总皂甙和地塞术松均能使∑ST和NST减少;并使缺血心肌 cGMP含量下降,而不影响cAMP。人参总皂甙的上述作用强度受给药后时间的影响。本文尚讨论了人参总皂甙抗心肌缺血作用的机制,认为其抗心肌缺血作用与降低cGMP 有关,但与糖皮质激素无关。更多还原

【Abstract】 Ginsenosides were extracted from panax ginseng C. A. Meyer according to the method of Shibata et al. A new model produced by two ligations of the left ventricular branch of the left coronary artery of rabbits was established. And the counteraction of the drugs on the myocardial ischemia was estimated by epicar-diac ECG ST mapping. It was showed that ginsenosides (50 mg/kg, iv) and dexame-thasone (5.5 mg/kg, iv)decreased the height of ST segment elevation (ΣST)and the number of ST elevating leads (NST). It was also found that these two drugs decreased cGMP level in the ischemic myocardium in rabbits, but did not affect cAMP. The results suggested that the mechanism of the counteraction of ginsenosides on myocardial ischemia Is similar to glucocorticoids which are considered stabilizing lysosomal membrane and protecting ischemic myocardium by way of decreasing cGMP level. The reason why the effects were stronger in the G70 group than in the G5 group remains to be elucidated. .It has been reported that ginsenosides have no glucocorticoid-like effects per se. We surveyed the effect of ginsenosides on the plasma cortisone level in rabbits and found that ginsenosides did not promote the release of cortisone. It was further indicated that the counteraction of ginsenosides on myocardial ischemia and the effects on cyclic nucleotides are not relative to plasma glucocorticoids.更多还原