【摘要】 <正> 四氧嘧啶能破坏胰岛细胞而引起糖尿病。医学上用它使动物致糖尿病,作为病理研究的模型;我们以¹⁴C标记它,供动物体内分布试验和基础医学研究使用。 1952年M.L.Tamayo等人首先合成2-¹⁴C-四氧嘧啶:是以¹⁴C-脲素与丙二酸二乙酯缩合制得[2-¹⁴C]-巴比妥酸,再与苯甲醛反应生成5-苄叉巴比妥酸,然后用氧化铬氧化成四氧嘧啶。其化学反应式如下:更多还原

【Abstract】 This paper describes synthesis of 2-14C-Alloxan from 14C-urea condensation with| malonic ester to form barbituric acid, and directly oxidization of it by chromium oxide.The yield of two steps was 50 %. The chemical and radiochemical purities of Alloxanassessed by paper chromatography were over than 95%. The specific activity of barbituricacid was 2.84 mCi/mmol and that of Alloxan was 2.46 mCi/mmol.更多还原