【摘要】 <正> 将低分子药物或有药理活性的基团,通过高分子化,所得的高分子药物,具有较高的为细胞吞噬或胞饮等活性,并期望它们在体内崩解缓释,与相应的低分子药物相比,可以发挥长效、低毒的优点。 1,2双-(3,5-二氧哌嗪-1)乙烷和(±)1,2双(3,5-二氧哌嗪-1)丙烷,是临床使用更多还原

【Abstract】 The oligomers containing 1,2-bis (3,5-dioxopyridazine-1) ethane (ICRF-154) and (±)-1,2-bis (3,5-dioxopyridazine-1) propane (ICBF-159) were prepared by reaction of 1,2-bis (3,5-dioxopyridazine-1) ethane or (±)-1,2-bis (3,5-dioxopyridazine-1) propane with various α, ω-dibromoalkanes in the presence of anhydrous potassium carbonate. The structural characteristics of the oligomers were investigated by IR and 1H-NMR. respecticvely.更多还原