【摘要】 <正> 多发性骨髓瘤是浆细胞的一种恶性肿瘤。Brunsteiner氏于五十年代首先对多发性骨髓瘤细胞的超微结构作了探讨。近年来国内始有研究。最近,我们应用透射与扫描电镜同时观察了2例多发性骨髓瘤,现报告如下: 材料与方法一、病例简介: 例1 男性,56岁,1979年发现面色苍白,于1980年3月在县医院诊断为多发性骨髓瘤,曾接受COP方案治疗而获得缓解。后因复发于1981年4月来我院门诊检查:贫血貌,胸骨有压叩痛,肝肋下7cm,脾肋下8cm。Hb6g,WBC4000,血片有幼粒和幼红细胞,浆细胞5%,红细胞呈缗钱状排列。血沉88mm/h,血清总蛋白8.4g%。免疫球蛋白电泳:IgG2400mg%。骨髓涂片瘤细胞90%(原浆细胞76%,幼浆细胞8.5%,网状细胞型5.5%)。尿本—周氏蛋白阴性。颅骨摄更多还原

【Abstract】 Bone marrow myeloma cells, chiefly the plasmablasts, from two patients who had multiple myeloma were examined by transmission and scanning electron -microscopy. ultrastructural differences between the myeloma cells and normal plasma cells were noted. The growth of the nucleus was slower than the cytoplasm of the plasmablasts. The cisternae of the rough endoplasmic reticulum (RER) varied from tubular to saclike in form, some were concentrically arranged. Close to a Golgi complex, electron-dense bodies of irregular form in the vacuoles of the cytoplasm were noted, they may be larly stages in the development of inclusion bodies. The surfaces of the myeloma cells were covered with microvilli, ruffles and bleb formation, an observation not entirely similar to that of Polliaok. However, bleb formation is probably not a specific characteristic of the plasma cells, as it has also been seen in acute myeloid leukemic cells.更多还原