节点文献
螯合剂对结合在人血清大分子上的镉的活动化能力的评价
Evaluation of the Mobilizing Ability of Chelating Agents toward Cadmium Bound to Human Serum Macromolecules
【摘要】 提出用镉在血清大分子与螯合剂间的分配比做为参数以评价各种螯合剂从血清大分子上活动镉的能力.这一数值可以用凝胶色谱法测定.用这样测定的分配比排出的螯合剂活动化能力顺序符合动物实验结果.因此,这种方法可以用来筛选螯合剂.讨论了用螯合剂活动金属离子的机理.
【Abstract】 The distribution ratio of cadmium between serum macromolecules and chelating agents under physiological condition is suggested as the measure for the evaluation of mobilizing abilities of various chelators toward cadmium bound to serum macromolecules. This ratio can be easily determined by means of gel chromatography.This distribution ratio arranging in decreasing series is agree well with that in vivo results. Thus this procedure is proposed as a method for the screening of chelators. The mechanism of the mobilization of metal ion with chelating agents is discussed.
- 【文献出处】 分子科学学报 ,Journal of Molecular Science , 编辑部邮箱 ,1984年03期
- 【下载频次】26