【摘要】 本工作研究了侧脑室内注射微量黄腐酸(0.3 mg/kg)对大鼠冷-限制引起的应激性胃粘膜损伤的影响。结果表明: 黄腐酸对应激性胃粘膜损伤具有明显的抑制作用,这种作用不能被酚妥拉明,心得安,纳洛酮和阿托品所阻断。但是否通过其他机制尚不能被排除。 侧脑室内注射酚妥拉明和阿托品本身也能明显地减少应激性胃粘膜损伤的发生,但与黄腐酸合用并不能加强以上的细胞保护作用。更多还原

【Abstract】 The effects of intracerebroventricular (ICV) injection of fulvic acid (0.3 mg/kg) on cold-restraint stress induced ulcer in rats were investigated.Fulvic acid significantly reduced the incidence of gastric stress mucosal lesions. This effect could not be blocked by phentolamine pro-pranolol, naloxone and atropine. However, the posibility that fulvic acid could exert its ulcerprotecting effect through other mechanisms cannot yet be excluded.Phentolamine and atropine (ICV) themselves, like fulvic acid, significantly reduced the incidence of gastric stress mucosal lesions. When given together of the two drugs (phentolamine plus fulvic acid or atropine plus fulvic acid) did not produce greater protection.更多还原