【摘要】 “吉林红丹三号”系一种新型祖国丹药复方制剂,主治脑血栓形成所致的偏瘫,临床试用有较好的疗效。本文为其毒理学及药效学提供依据。实验证明“三号”的急性毒性不明显;亚急性毒性表明相当于临床连续服用30天的量是安全的。根据“三号”的抗血栓形成作用及其对血栓弹力图的影响,其药效似乎与血液学的变化,特别是血小板及凝血功能有关。更多还原

【Abstract】 Jilin Red Panacea No. 3 " is a compound preparation based on the Chinese traditional panacea and folk remedy. It is primarily used for hemiplegia resulting from cerebral embolism and has reliable curative effect. Our study demonstrated that its acute toxic dosage was about 1,000 times that of the therapeutic dosage(by weight), amounting to about more than 15,151.5 mg/M2or 5,000mg/kg (LD50of mice,stomach perfusion) . No significant toxicity was observed when the animals (dogs) were given a dosage equivalent to that used in clinical trial for thirty days; only slight pathological changes were observed in the liver, kidney and testes when the dosage was equivalent to that used in clinical trial for 90 days. "Jilin Red Panacea No. 3" has been proved to be effective in anticoagulating the experimental platelet embolism. It is concluded that the administration of a dose of "No. 8 " equivalent to that used in clinical trial for 30 days is quite safe and that its pharmacodynamics is probably through its effect on the platelets.更多还原