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异体骨基质修复大块骨缺损的实验研究

An experimental study on bridging large hone defects with a decalcified granulated homologous cortical bone matrix

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【摘要】 本实验选用青蓝紫兔32只,将双侧挠骨中1/3骨干截除2cm,缺损区内一侧充填以脱钙异体骨颗粒(DGB),对侧充填非脱钙异体骨颗粒(UGB)或空置作为对照。结果发现术后9周处死的16只动物中,15只实验侧缺损区内形成了管状骨,其骨皮质与桡骨缺损二断端骨皮质融合连接,其中央骨髓腔与原桡骨髓腔连通。同体对照侧无1例修复。

【Abstract】 The rabbits were chosen as experimental animals. A 2cm long bone cylinder was removed from the diaphysis of both radii. The artificial bone defects were filled with decaleified granulated bone on one side, and as control, the other side was kept empty or filled with undecalcified granulated bone.9 weeks post-operatively, in the decalcified granulated bone site, new tubular bones well developed in 15/16 cases, which showed completely union to the proximal and distal ends of the defected radius cortex. Medullary canals were formed in the central parts of the new ossicles which communicated with the medullary cavity of theradius.No bone bridging was obtained either in the empty defects or in those filled with undecalcified granulated bone.

  • 【文献出处】 北京医学 ,Beijing Medical Journal , 编辑部邮箱 ,1984年04期
  • 【被引频次】13
  • 【下载频次】17
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